Police have set up a barrier at the steps of Flinders Street Station, where organisers told crowds to meet at 7pm.
The message coming out of protesters is to “make your voices heard” saying Melburnians cannot endure another lockdown.
One protester has already been arrested after allegedly standing in front of a moving tram.
Premier Daniel Andrews has heard about the protest and says he is not impressed.
“Having a protest tonight, that’s like a vaccine is it that’s suddenly going to fix everything?” Mr Andrews said.
“No it’s not. It might well spread the virus though and it’s not really a good thing to be doing.”