Police allege that the men – aged 24, 21, 20 as well as a 16-year-old boy – invited a group of girls to a party in Toowong last year.
At the party the girls were allegedly drugged and sexually assaulted repeatedly.
On Thursday, the men and boy were arrested by detectives with the assistance of Dog Squad, Tactical Crime Squad and other specialist units.
Each have been charged with seven counts of rape, three counts of administering a stupefying drug to commit rape, two counts of sexual assault, contravening direction and drug offences.
They will all appear before a Brisbane court today.
Police are asking any members of the public who may have further information to come forward.