The winning numbers were 6-9-17-18-48, with 8 as the Mega Ball.
The jackpot won in Pennsylvania is the highest amount won in the state since it became a Mega Millions participant in 2010.
The amount was the ninth-largest in Mega Millions history and the largest the game has ever awarded in the month of May, according to the statement.
Across the US, 53 tickets matched four numbers plus the Mega Ball to each win at least $10,000, Mega Millions said.
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