A truck has collided with five pedestrians in Melbourne, critically injuring two men.

Witnesses told police the truck left the road near the intersection of City Road and Power Street in Southbank about 7pm, hitting a traffic light and the pedestrians.

In all, four men and a woman believed to be in their 20s and 30s were injured.

Police said the truck, possibly a tanker, left the scene via Power Street but there was not thought to be any threat to the community.

Detectives from the major collision investigation unit are trying to identify the driver and want anyone who saw the incident or has dascham footage to come forward.

Ambulance Victoria said two of the injured men, believed to be in their 20s, were taken to the Alfred Hospital. One was in a critical condition, the other was serious but stable.

The other pedestrians, one critically injured and the other two in a serious but stable condition, were taken to the Royal Melbourne Hospital.

Paramedics said all five suffered lower-body injuries.

Anyone with information should call Crime Stoppers on 1800 333 000.

This content first appear on 9news

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