The teenager is understood to have been stabbed in the stomach at 8pm in Emma Miller Place near Roma Street.
He ran to the city’s King George Square to get help, and paramedics were called.
He was taken to the Royal Brisbane and Women’s Hospital but died three hours later.
9News understands the alleged killer ran through Roma Street Parklands and has not been found.
Police are looking at CCTV and are urging anyone with information to contact Crimestoppers on 1800 333 000.
This content first appear on 9news