A man is fighting for life and three more are in hospital after a violent road rage incident in Sydney’s south-west overnight.

Two groups of men in a Honda Civic and a ute were allegedly involved in an argument at an intersection of Henry Lawson Drive and the Hume Highway at Georges Hall around 10.45pm yesterday.

The ute allegedly then forced the Civic from the road and into bushland, where it rolled onto its roof.

Police are conducting an investigation after several men were seriously injured in a road rage incident in Sydney’s south-west overnight. (Nine)

The Civic driver, a 20-year-old man, and his passenger, a 17-year-old boy, managed to escape the car before being confronted by the second group of men.

The men from the ute then allegedly assaulted the pair, with the Civic driver stabbed in his left leg.

The ute then took off, driving north at high speed before colliding with a motorbike and a silver Toyota Camry.

The driver did not stop and continued travelling north along Henry Lawson Drive.

The 24-year-old motorcyclist is now fighting for life after being taken to Liverpool Hospital in a critical condition.

The road rage incident and alleged assault occurred on Henry Lawson Drive in Georges Hall. (Nine)

The male driver of the Toyota was also taken to hospital with chest injuries, along with the driver of the Honda – who remains in a serious but stable condition – after being stabbed.

The teenage passenger from the Honda was treated by paramedics at the scene for minor injuries.

Henry Lawson Drive between Flinders Road and Tower Road was closed this morning as police examined the scene.

Police have appealed for public assistance to identify the men who may be able to assist with their investigation.

Anyone with information about the incident, or has dashcam footage, is urged to contact Crime Stoppers on 1800 333 000.

This content first appear on 9news

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