The horror attack was carried out just before 4am today at a Calendar Place home in Woodville West.
9News understands the male victim is Todd Bradmore, who lived at the residence with his mother. The two women were in their 20s.
Neighbours were woken by desperate cries for help, with one of the women running on the street and banging on doors.
“She was just in pain, screaming in pain,” one witness said.
“Obviously it’s pretty concerning, it’s not great at all.”
Another said they had heard a man “moaning for at least about an hour, saying he was sorry, he was in pain, and saying, leave me alone”.
Police are searching for a man believed to be responsible for the attack.
It’s understood he set fire to at least one of the three victims.
The investigation is continuing.